Genome Instability in Cancer Development - Advances in Experimental Medicine and Biology 2005 edition

Marc Notes: Includes bibliographical references and index. Table of Contents: Preface -- List of Contributors -- Part 1. The Problem of Genome Instability -- 1.1. The Multiplicity of Mutations in Human Cancers / Ranga N. Venkatesan, Lawrence A. Loeb -- 1.2. Monitoring Chromosome Rearrangements / Michael R. Speicher -- Part 2. DNA Repair and Mutagenesis -- 2.1. Nucleotide Excision Repair and its Connection with Cancer and Ageing / Jaan-Olle Andressoo, Jan H. J. Hoeijmakers, Harm de Waard -- 2.2. DNA Mismatch Repair and Colon Cancer / Giancarlo Marra, Josef Jiricny -- 2.3. Base Excision Repair / Lisiane B. Meira, Nicholas E. Burgis, Leona D. Samson -- 2.4. DNA Double Strand Break Repair / Penny A. Jeggo -- 2.5. Translesion Synthesis and Error-Prone Polymerases / Catherine M. Green, Alan R. Lehmann -- Part 3. Cell Cycle Progression and Chromosome Aberration -- 3.1. The INK4A/ARF Network - Cell Cycle Checkpoint or Emergency Brake? / Ana Gutierrez del Arroyo, Gordon Peters -- 3.2. DNA Replication and Genomic Instability / Wenge Zhu, Tarek Abbas, Anindya Dutta -- 3.3. The Dream of every Chromosome: Equal Segregation for a Healthy Life of the Host / Tomohiro Matsumoto, Mitsuhiro Yanagida -- 3.4. Telomere Structural Dynamics in Genome Integrity Control and Carcinogenesis / Roger A. Greenberg, K. Lenhard Rudolph -- 3.5. Gene Amplification Mechanisms / Michelle Debatisse, Bernard Malfoy -- 3.6. DNA Methylation and Cancer-Associated Genetic Instability / Melanie Ehrlich -- 3.7. Deregulation of the Centrosome Cycle and the Origin of Chromosomal Instability in Cancer / Wilma L. Lingle, Kara Lukaswiewicz, Jeffrey L. Salisbury -- Part 4. Genome Integrity Checkpoints -- 4.1. Mammalian DNA Damage Response Pathway / Zhenkun Lou, Junjie Chen -- 4.2. ATM and Cellular Response to DNA Damage / Martin F. Lavin, Sergei Kozlov, Nuri Gueven, Cheng Peng, Geoff Birrell, Phillip Chen, Shaun Scott -- 4.3. Mitotic Checkpoint, Aneuploidy and Cancer / Tim J. Yen, Gary D. Kao -- Index.

Contributor Bio:  Nigg, Erich A Erich Nigg obtained his PhD in Biochemistry from the Swiss Federal Institute of Technology (ETH) in Zurich. After postdoctoral training in California, he directed research groups at the ETH and the Swiss Institute for Experimental Cancer Research, before being appointed Full Professor at the University of Geneva. In 1997, he became Director and Scientific Member of the Max-Planck Society, and has been head of the Cell Biology Department at the Max-Planck Institute for Biochemistry in Martinsried/Munich since October 1999. Professor Nigg's research interests are centered on cell cycle control, with a current focus on the regulation of the centrosome cycle, cell division, and the problem of chromosomal instability in cancer.